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MicroRNAs(miRNAs,miRs)是一类长度较短的(大约22个碱基)非编码RNA,在细胞增殖、分化和凋亡等多种生物学进程中发挥了重要作用[1-3]。miRs及其靶基因序列之间的低互补性使得一个miRs可以与多个的靶基因存在相互作用,因此miRs在诸多生物学通路和过程当中发挥了多种多样的复合效应。人类大概有50%~60%的蛋白编码基因可能受miRs的调节。本
MicroRNAs (miRNAs, miRs) are a class of shorter (about 22 bases) noncoding RNAs that play important roles in various biological processes such as cell proliferation, differentiation and apoptosis [1-3]. The low complementarity between miRs and their target sequences allows one miRs to interact with multiple target genes. Therefore, miRs exert a variety of complex effects in many biological pathways and processes. About 50% to 60% of human protein-coding genes may be regulated by miRs. this