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分析新生儿缺氧缺血性脑病(HIE)43例。有宫内窘迫史者占581%,出生重度窒息占814%。HIE轻度10例,中度26例,重度7例。合并心肌损害达417%。治愈好转率为813%。病死率70%。随访24例,轻度HIE预后好,中度有明显后遗症者为67%,重度预后不良。认为加强围生期保健,提高产科质量,进行新法复苏及复苏后处理是降低HIE发病率的关键。诊治中应重视心肌损害。使用胞二磷胆碱等脑细胞代谢激活剂辅治HIE效果肯定。对于预后,强调早期治疗,早期评分、早期随访、早期干预是改善重度HIE预后的几个重要环节。
Analysis of 43 neonates with hypoxic-ischemic encephalopathy (HIE). History of intrauterine distress accounted for 58 1%, severe asphyxia accounted for 81 4%. HIE mild in 10 cases, moderate in 26 cases, severe in 7 cases. Combined myocardial damage up to 41 7%. The healing improvement rate was 813%. Fatality rate was 7.0%. Follow-up 24 cases, mild HIE prognosis is good, moderate significant sequelae was 6.7%, severe prognosis. It is believed that the key to reducing the incidence of HIE is to strengthen the perinatal care, improve the quality of obstetrics, and carry out the recovery of the new law and post-recovery management. Diagnosis and treatment should pay attention to myocardial damage. The use of citicoline and other brain cell metabolism activator treatment of HIE positive effect. For the prognosis, emphasizing early treatment, early scoring, early follow-up, early intervention is to improve the prognosis of several important aspects of HIE.