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目的检测成人急性淋巴细胞白血病患者MLL基因及其白血病细胞免疫表达异常率。比较免疫异常及MLL基因对预后的影响。方法利用荧光定量技术检测MLL基因,并对白血病细胞系列进行特定的抗原标记。分析MLL基因及免疫异常的临床意义。结果 31例急性淋巴细胞白血病中5例检测到MLL基因,发生率为16.13%,在急性淋巴细胞白血病发生率较高,MLL基因在免疫表达异常中的检出率无明显差异。结论 RQ-PCR监测MLL基因可以观察治疗效果,MLL基因在急性淋巴细胞白血病发生率较高;免疫异常的患者MLL基因重排检出率无明显差异,免疫异常及MLL基因重排病例疗效差,提示基因重排及免疫异常表达与生存率有关。
Objective To detect abnormal expression of MLL gene and leukemia cells in adult patients with acute lymphoblastic leukemia. To compare the immune dysfunction and MLL gene prognosis. Methods The MLL gene was detected by fluorescence quantitative method and specific antigens were labeled in the leukemia cell line. To analyze the clinical significance of MLL gene and immune abnormalities. Results MLL gene was detected in 5 cases of 31 cases of acute lymphoblastic leukemia, the incidence rate was 16.13%. There was no significant difference in the detection rate of MLL gene in the abnormal expression of the immunopotency in acute lymphoblastic leukemia. Conclusions The detection of MLL gene by RQ-PCR can observe the therapeutic effect. The incidence of MLL gene in acute lymphoblastic leukemia is higher. The detection rate of MLL gene rearrangement is not significantly different in immunocompromised patients. The immune dysfunction and MLL gene rearrangement have poor curative effect, Tip gene rearrangement and abnormal immune expression and survival rate.