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硝苯吡啶越来越多地应用于缺血性心脏病的处理。该药可降低心肌的氧消耗,通过扩张血管,增加受累心肌的灌注;通过阻止过多钙离子的流入以保护心肌,从而保持染色体的完整性。目前该药已用于冠状动脉痉挛和阻塞性冠状动脉疾病所致的急性冠状动脉缺血的治疗。由于与低氧有关的电不稳定性和缺血心肌的再灌注所致的室颤(VF)可合并急性心肌缺血,明确硝苯吡啶是否具有抗心律不齐的作用很为重要。
Nifedipine is increasingly used in the treatment of ischemic heart disease. It reduces oxygen consumption in the heart muscle and increases myocardial perfusion by dilating blood vessels. It also maintains chromosomal integrity by preventing influx of excess calcium to protect the myocardium. The drug is currently used for the treatment of acute coronary ischemia caused by coronary artery spasm and obstructive coronary artery disease. Because of the electrical instability associated with hypoxia and ventricular fibrillation (VF) due to reperfusion of ischemic myocardium, acute myocardial ischemia can be combined to determine if nifedipine is refractory to arrhythmia.