作者于1986年12月至1988年6月对15例准备手术的乳腺癌患者应用米托蒽醌观察其治疗效果及疗后组织形态学改变。结果表明,用药7天后乳腺肿块均有不同程度缩小。手术切除标本镜下可见瘤细胞核染色体断裂,核固缩、线粒体破坏,出现空泡。间质中亦可见少数毛细血管及结缔组织增生性反应。在瘤细胞受到抑制的背景下选择手术时机,将对降低局部复发及远处转移带来好处。 From December 1986 to June 1988, the authors applied mitoxantrone to 15 breast cancer patients undergoing surgery to observe its therapeutic effect and histological changes after treatment. The results showed that after 7 days of treatment, breast masses were reduced to varying degrees. The resection of specimens under the microscope showed that the tumor cells had nuclear chromosome breakage, nuclear condensation, mitochondrial destruction and vacuolization. A few capillary and connective tissue proliferative responses are also seen in the stroma. Choosing the timing of surgery in the context of suppressed tumor cells will be beneficial for reducing local recurrence and distant metastasis.