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目的:观察前列地尔与加巴喷丁联合治疗痛性糖尿病神经病变的临床疗效。方法:将本院收治的82例痛性糖尿病神经病变患者随机的分为两组,对照组单独应用前列地尔治疗,而观察组则采用前列地尔联合加巴喷丁治疗,经过3周的治疗后,然后比较两组患者治疗前后的视觉模拟评分(VAS),运动末端潜伏期(ML),运动神经传导速度(MNCV)及感觉神经传导速度(SNCV)的变化情况。结果:两组患者的VAS均下降,组间差异有统计学意义(P<0.05);两组患者MNCV、ML及SNCV均有所改善,两组SNCV及ML差异有统计学意义(P<0.05),而MNCV差异无统计学意义(P>0.05)。结论:前列地尔与加巴喷丁联合应用于治疗痛性糖尿病神经病变的效果良好。
Objective: To observe the clinical efficacy of alprostadil and gabapentin in the treatment of painful diabetic neuropathy. Methods: 82 cases of diabetic neuropathy patients admitted to our hospital were randomly divided into two groups. The control group was treated with alprostadil alone, while the observation group was treated with alprostadil combined with gabapentin. After three weeks of treatment, The changes of visual analog scale (VAS), motor end latency (ML), motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) before and after treatment were compared between the two groups. Results: The VAS of both groups decreased, with significant difference between the two groups (P <0.05). The MNCV, ML and SNCV of both groups were improved, the differences of SNCV and ML between the two groups were statistically significant (P <0.05 ), While there was no significant difference in MNCV (P> 0.05). Conclusion: The combination of alprostadil and gabapentin has a good effect on the treatment of diabetic neuropathy.