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目的探讨吸烟对男性精浆一氧化氮、微量元素及精子三磷酸腺苷(ATP)水平的影响。方法 124例男性不育患者根据有无吸烟分为不育非吸烟组和不育吸烟组,不育吸烟组又根据吸烟习惯和烟龄分为3组:A组日吸烟量<10支,且烟龄<5年;B组日吸烟量10~20支,且烟龄5~10年;C组日吸烟量>20支,且烟龄>10年。选择35例已生育正常健康男性为正常对照组。检测其精浆一氧化氮、微量元素及精子ATP的水平。结果不育吸烟组和不育非吸烟组较正常对照组精浆一氧化氮、铅和镉水平明显升高,锌、铜和精子ATP水平明显降低,差异均有统计学意义(P<0.05),不育吸烟组较不育非吸烟组精浆一氧化氮、铅和镉水平明显升高,锌、铜和ATP水平明显降低,差异均有统计学意义(P<0.05)。C组精浆一氧化氮、铅和镉水平均显著高于A组和B组,锌、铜和精子ATP水平均显著低于A组和B组,差异有统计学意义(P<0.05)。结论吸烟可以影响精浆一氧化氮、微量元素及精子ATP的水平,与不育密切相关。
Objective To investigate the effects of smoking on the levels of nitric oxide, trace elements and sperm adenosine triphosphate (ATP) in male seminal plasma. Methods 124 male infertility patients were divided into sterile non-smoking group and sterile smoking group according to the presence or absence of smoking. The sterile smoking group was also divided into 3 groups according to smoking habits and smoking age: Group A daily smoking amount <10, and The smoking age was less than 5 years; the daily smoking amount in group B was 10 to 20 cigarettes, and the smoking time was 5 to 10 years; the daily smoking amount in C group was more than 20 cigarettes and the smoking age was more than 10 years. 35 cases of normal healthy males were selected as the normal control group. Detection of its seminal plasma nitric oxide, trace elements and sperm ATP levels. Results Compared with the control group, the levels of NO, Pb and Cd in infertile and non-smokers groups were significantly increased, while the levels of ATP in zinc, copper and sperm were significantly decreased (P <0.05) (P <0.05). The levels of NO, Pb and Cd in seminal plasma of infertile smoking group were significantly higher than those of infertile non-smoking group, while the levels of Zn, Cu and ATP were significantly decreased (P <0.05). The levels of nitric oxide, lead and cadmium in seminal plasma in group C were significantly higher than those in groups A and B, and the levels of ATP in zinc, copper and sperm were significantly lower than those in groups A and B (P <0.05). Conclusion Smoking can affect the levels of nitric oxide, trace elements and sperm ATP in seminal plasma, which is closely related to infertility.