【摘 要】
：
Solute carrier (SLC) transporters meditate many essential physiological functions,including nutrient uptake,ion influx/efflux,and waste disposal.In its protecti
【机 构】
：
School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Bi
论文部分内容阅读
Solute carrier (SLC) transporters meditate many essential physiological functions,including nutrient uptake,ion influx/efflux,and waste disposal.In its protective role against tumors and infections,the mammalian immune system coordinates complex signals to support the proliferation,differentiation,and effector function of individual cell subsets.Recent research in this area has yielded surprising findings on the roles of solute carrier transporters,which were discovered to regulate lymphocyte signaling and control their differentiation,function,and fate by modulating diverse metabolic pathways and balanced levels of different metabolites.In this review,we present current information mainly on glucose transporters,amino-acid transporters,and metal ion transporters,which are critically important for mediating immune cell homeostasis in many different pathological conditions.
其他文献
Overexpression of exogenous lineage-determining factors succeeds in directly reprogramming flbroblasts to various cell types.Several studies have reported repro
农作物杂种优势以应用细胞质雄性不育(Cytoplasmic Male Sterility, CMS)最为普遍。中国籼型三系杂交稻大面积利用野败型(WA)不育细胞质长达30余年,近年在生产上虽逐渐增加了新资源CMS的应用,但90%仍与野败型属于同一遗传类型,长期大面积种植同一遗传类型细胞质的杂交稻存在巨大的潜在风险,因此研究利用新遗传类型的CMS,比较不同类型CMS的遗传特异性,对于探索新细胞质源C
云南省工商行政管理局云南省农业厅转发国家工商行政管理局农业部《关于加强肥料、农药、种子市场管理的通知》的通知（１９９４年２月１７日）各地、州、市、县工商行政管理局、农（牧）业局：为了保
Long-term primary culture of mammalian cells has been always difficult due to unavoidable senescence.Conventional methods for generating immortalized cell lines
小麦赤霉病是一种主要由禾谷镰刀菌引起的世界性流行病害,严重危害小麦产量、品质和粮食安全。选育抗赤霉病小麦品种是控制麦类赤霉病最经济、环保和有效的途径。望水白是我国地方品种,是重要的高抗赤霉病遗传资源。为了进一步明确望水白赤霉病抗性的分子机制,促进其在小麦抗赤霉病遗传改良中的有效利用,本研究以望水白和Alondras为亲本构建的重组自交系为作图群体,在构建分子标记遗传连锁图谱基础上,采用单花滴注和喷
为了探索半干旱地区沟垄集雨种植模式下不同施肥水平对旱地谷子生长、产量及水肥利用效率的影响,本试验以大同29为试材,设置两种种植模式(沟垄集雨种植R、传统裸地平作T),和四个施肥水平(不施肥F0,低量施肥F1:N 93kg/hm2+P2O548 kg/hm2,中量施肥F2:N186 kg/hm2+P2O5 96 kg/hm2,高量施肥F3:N 279 kg/hm2+P2O5 144 kg/hm2),
大豆基因组测序已经完成并发表。全长cDNA文库因其能够提供完整的基因序列信息,有助于准确分析基因的结构和功能,能够促进大豆基因组数据的有效利用和功能基因组学的研究和发展,已成为目前分子生物学领域的一种重要途径。本研究以我国栽培大豆品种绥农14为材料,运用SMART方法构建成4个高质量的全长cDNA文库,从中鉴定出2,071条全长基因,并对其基因结构、基因功能和代谢途径等进行注释,探讨大豆核基因密码
Protein neddylation is a post-translational modification which transfers the ubiquitin-like protein NEDD8 to a lysine residue of the target substrate through a
Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene,which is frequently mutated in breast and ovarian cancers.BRCA1 plays a key role in the h
In order to improve the positional adaptability of our previously reported naphthyl diaryltria-zines (NP-DATAs),synthesis of a series of novel biphenyl-substitu