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目的 研究上海地区 2 0 5名绝经后妇女Ⅰ型胶原α1(COLIA1)基因Sp1结合位点的多态性变化与骨密度的关系。方法 用PCR RFLP法检测COLIA1基因多态性 ,基因型中的大写和小写字母 (S和s)分别表示无和有限制性内切酶位点。以双能X线骨密度仪测定腰椎和股骨颈等处骨密度。结果所有样本均为SS基因型 ,没有发现Ss和ss型。结论 COLIA1基因多态性可能有较大的种族差异 ,与上海地区绝经后妇女的骨密度无关。该基因对骨密度和骨质疏松症的影响尚需在不同人群中进一步研究
Objective To investigate the relationship between the polymorphism of Sp1 binding site of type Ⅰ collagen (COLIA1) gene and bone mineral density in 205 postmenopausal women in Shanghai. Methods Polymorphisms of COLIA1 gene were detected by PCR RFLP. Uppercase and lowercase letters (S and s) in genotypes were used to identify the polymorphic sites of the COLIA1 gene. Dual-energy X-ray absorptiometry was used to determine the bone density of lumbar and femoral neck. Results All samples were SS genotypes, no Ss and ss were found. Conclusion COLIA1 gene polymorphism may have a greater racial difference, and has nothing to do with the BMD of postmenopausal women in Shanghai. The impact of this gene on bone mineral density and osteoporosis needs to be further studied in different populations