Jeddah-Makkah regionis have been suffering from earthquake crisis where some moderate to destructive earthquakes have been recorded. These earthquake activities are oriented along major faults or clustered in certain spots. Moreover, these earthquake events have annual recurrence periods, so the identification of these seismogenic source zones is of utmost importance for mapping the most hazardous localities which should be avoided in the future urban planning. Historical and instrumental earthquakes have been collected from national and international data centers and unified in catalogue. The existence of microearthquakes inland suggests that there is a significant level of tectonic activity at away from the axial trough of the Red Sea. Then, seismogenic source zones have been defined depending on the major tectonic trends; distribution of earthquake epicenters, seismicity rate(a & b- values) and fault plane solution of major earthquakes. It is concluded that Jeddah-Makkah region is affected by the outlined five seismogenic source zones; three of these zones aligned of the main Red Sea axial trough(southwestern Jeddah, western Jeddah, and northwestern Jeddah zones), while the other two zones are located in the land area of the region(Thewal-Rabegh and Jeddah-Makkah zones). These inland zones correlated well with the main trends of major tectonics which refleet the reactivation of tectonic movements along these fault trends. The Red Sea zones are in agreement with the main path of the axial trough. The range of b-value in these identified zones is 0.65 to 1.03 through these identified zones. The area characterized by higher b-values could be indicative of a relative low stress regime which was a result of resulting from the stress release by the earthquakes. Whereas, the areas of lower b-values can be considered as an evidence of a relatively higher stress regime associated with a dominantly extensional stresses. Based on aforementioned, the region is suffering from different stress level accumulations which, in turn, cause earthquakes with different magnitudes. Accordingly, deployment of local seismograph network through Jeddah-Makkah region is highly recommended. These results will support, to a great extent, seismic hazard assessment and risk mitigation of the region. Jeddah-Makkah regionis have been suffering from earthquake crisis where some moderate to destructive earthquakes have been recorded. These earthquake activities are oriented along major faults or clustered in certain spots. Moreover, these earthquake events have annual recurrence periods, so the identification of these seismogenic source zones is of utmost importance for mapping the most hazardous localities which should be avoided in the future urban planning. Historical and instrumental earthquakes have been collected from national and international data centers and unified in catalog. The existence of microearthquakes inland suggests that there is a significant level of tectonic activity at away from the axial trough of the Red Sea. Then, seismogenic source zones have been defined depending on the major tectonic trends; distribution of earthquake epicenters, seismicity rate (a & b- values) and fault plane solution of major earthquakes. It is said that Jeddah-Makkah region is a ffected by the outlined five seismogenic source zones; three of these zones aligned of the main Red Sea axial trough (southwestern Jeddah, western Jeddah, and northwestern Jeddah zones), while the other two zones are located in the land area of ​​the region (Thewal -Rabegh and Jeddah-Makkah zones). These inland zones correlated well with the main trends of major tectonics which refleet the reactivation of tectonic movements along these fault trends. The Red Sea zones are in agreement with the main path of the axial trough. range of b-value in these identified zones is 0.65 to 1.03 through these identified zones. The area characterized by higher b-values ​​could be indicative of a relative low stress regime which was a result of resulting from the stress release by the earthquakes. Whereas , the areas of lower b-values ​​can be considered as an evidence of a relatively higher stress regime associated with a dominantly extensional stresses. Based on the, the region is suffering fromdifferent, stress level accumulations which, in turn, cause earthquakes with different magnitudes. These, deployment of local seismograph network through Jeddah-Makkah region is highly recommended. These results will support, to a great extent, seismic hazard assessment and risk mitigation of the region .