甘油二酯酰基转移酶(DGAT)被认为是控制高甘油三酯所致疾病,如肥胖、高甘油三酯血症等的潜在标靶。作者以生物活性为导向,从人参石油醚提取物(对DGAT具抑制活性)中分得2个新的多炔化合物,研究了它们对DGAT的抑制活性。将4年生人参鲜根用石油醚于室温下提取3d,共2次。所得提取物经硅胶柱层析,己烷-乙酸乙酯梯度洗脱,根据TLC特征分得18个部位。将对DGAT具抑制活性的第8～10部位进行低压液相色谱分离,得到3个次 Diacylglycerol acyltransferase (DGAT) is thought to be a potential target for controlling high triglyceride-induced diseases such as obesity, hypertriglyceridemia, and the like. The authors took bioactivities as the guide, and obtained two new polyacetylene compounds from the ginseng petroleum ether extract (having inhibitory activity against DGAT), and studied their inhibitory activities against DGAT. The fresh roots of 4-year-old ginseng were extracted with petroleum ether at room temperature for 3 days for a total of 2 times. The resulting extract was subjected to silica gel column chromatography and eluted with a gradient of hexane-ethyl acetate to obtain 18 sites according to the TLC characteristics. The 8th to 10th parts of the DGAT inhibitory activity were separated by low pressure liquid chromatography to obtain 3 times