四氢呋喃环广泛存在于具有生物活性的天然产物结构当中,立体选择性地构筑四氢呋喃环往往成为这些天然产物全合成研究中的关键。本文归纳了已有全合成报道中的四氢呋喃环成环策略,以实例展示了其中的会聚式合成策略在近年的发展。相比于直线型的分子内关环策略,以[4+1]、[3+2]为代表的会聚式四氢呋喃关环策略往往能够使全合成的整体路线更加简洁高效,更符合全合成研究领域的发展趋势。 Tetrahydrofuran ring exists widely in the biological activity of the natural product structure, stereoselective ring structure of tetrahydrofuran often become the natural synthesis of these natural products in the key. In this paper, we summarize the ring-forming strategy of tetrahydrofuryl ring in all the reported syntheses and show the recent development of the convergent synthesis strategy. Compared with the linear intramolecular ring closure strategy, the convergent tetrahydrofuran ring closure strategy represented by [4 + 1] and [3 + 2] tends to make the total synthesis more concise and efficient and more in line with the all-synthetic study The development trend of the field.