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目的:观察柔肝化纤颗粒联合阿德福韦酯治疗慢性乙型肝炎肝纤维化临床疗效。方法:100例慢性乙型肝炎肝纤维化患者,随机分为观察组和对照组,各50例。2组均接受常规保肝治疗基础治疗;对照组服用阿德福韦酯或其他常规保肝药物;观察组在对照组治疗基础上加用柔肝化纤颗粒治疗。观察1肝功能指标谷丙转氨酶(ALT)、白蛋白(Alb)、总胆红素(TBil);2纤维化指标透明质酸酶(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、IV型胶原(Ⅳ-C);3门脉主干内径、门脉流速、脾脏厚度。结果:2组治疗后ALT、Alb、TBil与治疗前比较,差异均有统计学意义(P<0.05);2组治疗后肝功能各项指标比较,差异均有统计学意义(P<0.05)。2组治疗后HA、LN、PCⅢ、Ⅳ-C与治疗前比较,差异均有统计学意义(P<0.05);2组治疗后肝纤维化各项指标比较,差异均有统计学意义(P<0.05)。2组治疗后门脉主干内径、门脉最大流速、脾脏厚度与治疗前比较,差异均有统计学意义(P<0.05);2组治疗后各项指标比较,差异均有统计学意义(P<0.05)。结论:柔肝化纤颗粒联合阿德福韦酯有利于阻断或逆转纤维化的形成。
Objective: To observe the clinical efficacy of Rougan chemical fiber granule combined with adefovir dipivoxil in treatment of chronic hepatitis B liver fibrosis. Methods: One hundred patients with chronic hepatitis B liver fibrosis were randomly divided into observation group and control group, 50 cases each. The two groups received routine hepatoprotective therapy; the control group received adefovir dipivoxil or other conventional hepatoprotective drugs; the observation group was treated with Rougan Chemical Fiber Granules on the basis of the control group. 1 liver function indicators of ALT, Alb, TBil; 2 fibrosis indicators of hyaluronidase (HA), laminin (LN), type Ⅲ procollagen PCⅢ), type IV collagen (Ⅳ-C); 3 portal vein diameter, portal flow velocity, spleen thickness. Results: There was significant difference of ALT, Alb and TBil between the two groups before treatment (P <0.05). The indexes of liver function in two groups after treatment were significantly different (P <0.05) . The difference of HA, LN, PCⅢ, Ⅳ-C between the two groups after treatment was statistically significant (P <0.05). The indexes of liver fibrosis in two groups after treatment were significantly different (P <0.05). After treatment, the main diameter of portal vein, the maximum flow velocity of portal vein and spleen thickness were significantly different between the two groups after treatment (P <0.05), and the differences were statistically significant (P <0.05). Conclusion: Rougan chemical fiber particles combined with adefovir dipivoxil help block or reverse the formation of fibrosis.