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目的：研究对苯二甲酸（TPA）的致畸毒性，为制订卫生标准提供依据。方法：选择受孕的SD大鼠，通过灌胃途径在妊娠第7天给予TPA，剂量组分别为：5000、500、50mg／kg，对照组给予等量植物油，妊娠第20天断颈处死动物，检查胎鼠内脏和骨骼有无异常。结果：5000mg／kg剂量组母鼠体重增长量、胎鼠体重、体长均低于对照组（P＜0．05），胎鼠内脏检查未见异常，骨骼检查仅见几例波状肋但无统计意义，其它未见异常。结论：本次研究结果提示，TPA在本次试验条件下无致畸毒性。
Objective: To study the teratogenicity of terephthalic acid (TPA) and provide the basis for the development of health standards. Methods: Pregnant SD rats were selected and given TPA by gavage on day 7 of pregnancy. The dosage groups were 5000, 500 and 50 mg / kg respectively. The control group was given the same amount of vegetable oil, the animals were sacrificed on day 20 of gestation, Check fetal rat internal organs and bone with or without abnormalities. Results: The body weight gain, body weight and body length of the 5000mg / kg dose group were lower than those of the control group (P <0.05). There were no abnormalities in the viscera examination of the fetal rats, but only a few cases Meaning, the other without exception. Conclusion: The results of this study suggest that TPA has no teratogenicity under this test condition.