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在Hartly系豚鼠生产群中,两次发生以结膜炎和颈部淋巴结肿胀化脓为主要病变的鼠伤寒沙门氏菌的自发流行病例。据此提示,结膜是本菌感染的重要途径。为了确认这个推断,用豚鼠进行了点眼、口服和同居3种感染实验。研究结果证明,点眼法的感染率比口服法为高,除发生结膜炎外,颈部淋巴结病变形成率亦非常高。经结膜感染的豚鼠,与自然感染例同样,主要是在颈部淋巴结、结膜和上呼吸道带菌。而经口感染例中,则显示出本菌在豚鼠体内广泛分布。用4株不同菌株进行感染实验和同居感染都获得了与
In the Hartley-derived guinea pig production group, spontaneous epidemics of S. typhimurium, a major lesion of conjunctivitis and swelling of the cervical lymph nodes, occurred twice. It is suggested that conjunctiva is an important way of infection of the bacteria. To confirm this hypothesis, guinea pigs were spotted, oral and cohabitation of three kinds of infection experiments. The results show that the infection rate of point eye method is higher than the oral method, in addition to the occurrence of conjunctivitis, the incidence of cervical lymph node disease is also very high. Guinea pigs infected by the conjunctiva, like the natural infection, are mainly carried in the cervical lymph nodes, conjunctiva and upper respiratory tract. Oral infections in the case, it shows that the bacteria widely distributed in guinea pigs. Infection experiments with 4 different strains and cohabitation infections were obtained