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为增加乙草胺的持效性,将乙草胺与氯化钙-十二烷基硫酸钠溶液混合后与碳酸钠反应制得乙草胺碳酸钙微球。通过扫描电镜、粒径分布仪及高效液相色谱等对该微球进行了表征,并对制备工艺、载药率及缓释性能等进行了探讨。结果表明:碳酸钙载体晶型主要为方解石结构;常温条件下,当n(CaCl2)∶n(Na2CO3)∶n(SDS)=1∶2∶2、搅拌速率为500 r/min、搅拌时间为10 min时,损耗率为0.2%,载药率接近20%;所得碳酸钙微球呈球形,粒径分布窄,且呈正态分布;微球中乙草胺的释放速率随温度和pH值的升高而增加。该微球制备工艺的优化及缓释性能研究结果可为田间定时、定量的释药研究及应用提供参考。
Acetochlor calcium carbonate microspheres were prepared by mixing acetochlor with calcium chloride-sodium lauryl sulfate solution and then reacting with sodium carbonate to increase the retention of acetochlor. The microspheres were characterized by scanning electron microscopy, particle size distribution and high performance liquid chromatography, and the preparation technology, drug loading rate and sustained release properties were discussed. The results showed that the crystal structure of calcium carbonate was mainly calcite. Under normal temperature conditions, when the stirring speed was 500 r / min and the stirring time was n (CaCl2): n (Na2CO3): n (SDS) = 1: 10 min, the rate of loss was 0.2% and drug loading rate was close to 20%. The resulting calcium carbonate microspheres were spherical with narrow particle size distribution and showed a normal distribution. The release rate of acetochlor in the microspheres varied with temperature and pH Increase and increase. The microspheres preparation process optimization and sustained-release properties of the research results for the field of fixed-dose, quantitative drug release studies and applications provide a reference.