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目的:研究黄秋葵黄酮抗小鼠运动性疲劳的作用及其机理。方法:清洁级ICR小鼠随机分为五组:分别给予低、中、高剂量黄秋葵黄酮75、150、300 mg·kg-1·d-1和蒸馏水(空白对照组)、生晒参水提液200 mg·kg-1·d-1(阳性对照组)连续灌胃21 d。测定小鼠负重游泳时间、血清尿素氮、肝糖原和血乳酸含量。结果:黄秋葵黄酮能明显延长小鼠负重游泳时间(P<0.05)、提高肝糖原含量(P<0.05)、降低血清尿素氮和乳酸水平(P<0.05),其效果与生晒参水提液相当(P>0.05)。结论:黄秋葵黄酮具有抗小鼠运动性疲劳的作用,其作用机理可能通过提高肝糖原含量、增加运动时的能源供给、减少蛋白质的分解和葡萄糖的无氧酵解、提高产能效率而发挥作用。
Objective: To study the effect and mechanism of flavonoids of okra against exercise-induced fatigue in mice. Methods: Clean-grade ICR mice were randomly divided into five groups: low, medium and high doses of okra flavonoids 75,150,300 mg · kg-1 · d-1 and distilled water (blank control group) Liquid 200 mg · kg-1 · d-1 (positive control group) for 21 days. The weight-bearing swimming time, serum urea nitrogen, hepatic glycogen and blood lactic acid in mice were measured. Results: Flavonoids of okra could prolong the weight-bearing swimming time (P <0.05), increase the content of hepatic glycogen (P <0.05) and the level of serum urea nitrogen and lactate (P <0.05) Liquid equivalent (P> 0.05). CONCLUSION: Flavone of okra possesses anti-fatigue effect on mice. Its mechanism of action may play its role by increasing the content of hepatic glycogen, increasing energy supply during exercise, reducing the decomposition of protein and anaerobic glycolysis, and increasing the production efficiency .