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肿瘤坏死因子（ＴＮＦ）在冠心病中有重要意义，对ＴＮＦ与ＭＤＡ、ＣＥＣ在急性心梗动物模型中作用及相互关系作一观察，通过动物模型急性心梗组（ＡＭＩ），心梗加用ＴＮＦα单克隆抗体组（ＡＴＭ）和对照组（Ｃ组）实验观察，结果为心梗坏死区占左心室的体积百分数ＡＭＩ组显著高于ＡＴＭ组。ＡＭＩ组ＴＮＦ含量显著高于Ｃ组，而ＡＴＭ组在实验中给予ＴＮＦα单克隆抗体，检测结果为０，ＡＭＩ组血浆ＭＤＡ显著高于Ｃ组和ＡＴＭ组。ＡＭＩ组全血中ＣＥＣ含量显著高于Ｃ组和ＡＴＭ组，推测急性心梗中ＴＮＦα含量升高可加重缺血区心肌细胞和血管内皮的进一步损伤，增加脂质氧化而ＴＮＦα单克隆抗体可明显减轻这些作用，故ＴＮＦα特异抗体在ＡＭＩ早期治疗中有一定应用价值
Tumor necrosis factor (TNF) is of great significance in coronary heart disease. The effects of TNF, MDA and CEC in animal models of acute myocardial infarction were observed. The animal models of acute myocardial infarction (AMI), myocardial infarction TNFα monoclonal antibody group (ATM) and control group (C group) experimental observation, the results for myocardial infarction necrosis area accounted for the percentage of left ventricular volume was significantly higher in the AMI group ATM group. The level of TNF in AMI group was significantly higher than that in group C, while the group of ATM was given TNFα monoclonal antibody in the experiment. The test result was 0, the level of MDA in AMI group was significantly higher than that in C group and ATM group. The level of CEC in whole blood of AMI group was significantly higher than that of C group and ATM group. It is speculated that the increase of TNFα in acute myocardial infarction could aggravate the further damage of myocardial cells and vascular endothelium in ischemic area, increase the lipid oxidation and the monoclonal antibody of TNFα obviously To alleviate these effects, so TNFα specific antibodies in the early treatment of AMI has a certain value