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为了全面了解人类鼻咽癌发生及发展的过程,在动物诱发鼻咽癌是一个重要的措施。迄今尚未见在文献上有关于在动物原位鼻咽成功诱发癌瘤的报导。侯宝璋(1960)曾用甲基胆蒽的油性溶液滴入小鼠鼻腔,结果引起了鼻孔的癌。广州中山医学院罗安泰等(1962)曾用甲基胆蒽或苯吡喷射到家兔、大鼠、小鼠及狗的鼻咽部,经过两年的时间,仍未出现鼻咽癌。区宝祥于1963年报导,在小鼠鼻咽管内注入二甲
In order to fully understand the process of human nasopharyngeal carcinogenesis and development, it is an important measure to induce nasopharyngeal carcinoma in animals. To date, there have been no reports in the literature on the successful induction of cancer in the animal’s orthotopic nasopharyngeal. Hou Baojun (1960) used methylated oil solution of methyl-cholesterol to inject into the nasal cavity of mice, resulting in cancer of the nostrils. Luo Antai et al. (1962) of Guangzhou Sun Yat-Sen School of Medicine had used methylcholanthrene or phenylpyrazine to inject into the nasopharynx of rabbits, rats, mice and dogs. After two years, no nasopharyngeal cancer has yet occurred. District Baoxiang reported in 1963 that it injected into the nasal nasopharyngeal tube of mice.