美国北卡罗林那大学的研究人员最近发现了一种被称为“守门员”的蛋白质,这种蛋白能防止血小板互相黏着,从而能控制血凝块的形成。这项研究发表在1月17日出版的Cell Biology杂志上,研究人员指出,C1B1蛋白能与血小板表面的血小板黏着受体GPⅡb／Ⅲa结合并使之处于失活状态。研究负责人Weiping Yuan博士认为,C1B1蛋白在GPⅡb／Ⅲa受体的活化过程中发挥着“守门员“的作用。“一开始,我们以为C1B1蛋白能活化GPⅡb／Ⅲa受体,但事实出乎我们的意料, Researchers at the University of North Carolina in the United States recently discovered a protein called a “gatekeeper,” a protein that prevents platelets from sticking to each other and controls blood clot formation. The study, published in the January 17 issue of Cell Biology, said that the C1B1 protein binds to and inactivates platelet-derived platelet adhesion receptors GPIIb / IIIa. According to Dr. Weiping Yuan, the research leader, C1B1 plays a role as a “gatekeeper” in the activation of GPⅡb / Ⅲa receptors. "At the beginning, we thought that C1B1 protein activated GPⅡb / Ⅲa receptor, but the fact was beyond our expectation.