论文部分内容阅读
本文研究了在窦律时和心脏起搏时蝙蝠葛碱(Dau)、普卡胺(pro)和利多卡因(Lid)对体表ECG的影响。Dau能明显延长QRS时间,轻度延长QT间期,QT延长主要是由于QRS时间延长所致,而它对JT间期的影响甚微。Pro同时延长QRS时间和JT间期,从而使QT间期明显延长。Lid通过缩短JT间期使QT间期缩短,它对QRS时间无何影响。结果表明,Dau对ECG的影响与Pro和Lid明显不同,而与晚近报道的Ic类抗心律失常药对ECG的影响相近。
This article investigates the effects of Dau, pro and lidocaine on the body surface ECG during sinus rhythm and cardiac pacing. Dau significantly prolonged QRS duration and slightly prolonged QT interval. QT prolongation was mainly due to prolonged QRS duration with little effect on JT interval. Pro prolongs both QRS and JT intervals, resulting in a significantly longer QT interval. Lid shortens the QT interval by shortening the JT interval, which has no effect on QRS duration. The results showed that the effects of Dau on ECG were significantly different from those on Pro and Lid, and similar to those reported recently for type Ic antiarrhythmic drugs.