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目的:研究肿瘤浸润调节性T淋巴细胞(Treg)在TNM分期II期结肠癌癌巢、癌间质中的数量及其临床意义。方法:采用免疫组化技术检测49例原发性II期结肠腺癌局部浸润Treg细胞的分布,并分析其临床意义。结果:癌组织中浸润的Treg细胞数量与年龄、性别及肿瘤大小无关(均P>0.05);高中分化癌组织Treg细胞数量多于中低分化组癌组织,癌巢中浸润的Treg细胞数量低于癌间质中浸润的Treg细胞数量(P<0.001);癌组织Treg细胞高数量组、癌间质Treg细胞高数量组的总生存率(OS)分别明显高于癌组织Treg细胞低数量组与癌间质Treg细胞低数量组(均P<0.05);癌巢Treg细胞高数量组的OS低于癌巢Treg细胞低数量组,但差异无统计学意义(P=0.299)。结论:Treg细胞在II期结肠癌癌巢及癌间质中发挥不同的作用,癌组织、癌间质及癌巢中浸润的Treg细胞数量可能分别是影响结肠癌临床预后的预测指标。
Objective: To study the quantity and clinical significance of tumor-infiltrating regulatory T lymphocytes (Tregs) in TNM stage II colon cancer neoplasms and cancer stroma. Methods: The distribution of locally infiltrating Treg cells in 49 patients with primary stage II colon adenocarcinoma was detected by immunohistochemistry and its clinical significance was analyzed. Results: The number of infiltrating Treg cells in cancer tissue was not related to age, gender and tumor size (all P> 0.05). The number of Treg cells in high differentiated cancer tissues was more than that in moderately and poorly differentiated cancer tissues, and the number of infiltrating Treg cells in cancer nests was low The number of Treg cells infiltrating into the interstitial stroma (P <0.001). The overall survival rates of high numbers of Treg cells in cancer tissues and high numbers of Treg cells in cancer stroma were significantly higher than those in low numbers of Treg cells in cancer tissues (P <0.05). The OS of high Treg cells in cancer nests was lower than that of Treg cells in cancer nests, but the difference was not statistically significant (P = 0.299). CONCLUSION: Treg cells play different roles in the stage II colon cancer neoplasms and cancer stroma. The number of Treg cells infiltrating into cancer tissues, cancer stroma and cancer nests may be the predictors of the prognosis of colon cancer.