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目的:讨论不稳定性心绞痛(UA)患者肌钙蛋白(cTnI)水平与冠状动脉病变的关系及临床预测价值。方法:120例不稳定性心绞痛患者根据肌钙蛋白I(cTnI)分cTnI阳性组45例,阴性组75例。120例患者住院期间均行冠脉造影(CAG)。对比两组UA患者冠状动脉特点及近期(30 d)心脏事件发生及预后。结果:cTnI阳性组冠脉造影阳性率91.1%,三支病变发生率51.1%。均明显高于cTnI阴性组。cTnI水平于冠状动脉狭窄程度有相关性。cTnI阳性组30 d心脏事件发生率35.6%,亦明显高于cTnI阴性组,两组对比差异均有显著性(P<0.01)。结论:cTnI阳性的UA患者冠状动脉病变复杂,愈后差。cTnI水平越高,冠脉狭窄越重,短期心脏事件率越高。
Objective: To investigate the relationship between the level of troponin (cTnI) and coronary artery disease in patients with unstable angina (UA) and its clinical value. Methods: Forty-five cTnI positive patients and 75 negative patients according to cTnI in 120 patients with unstable angina. All 120 patients underwent coronary angiography (CAG) during hospitalization. The characteristics of coronary artery in the two groups of UA patients and the occurrence and prognosis of the recent cardiac events (30 days) were compared. Results: The positive rate of coronary angiography in cTnI positive group was 91.1% and the incidence of three lesions was 51.1%. Were significantly higher than the cTnI negative group. The level of cTnI was correlated with the degree of coronary artery stenosis. The incidence of cardiac events at 30 d in cTnI positive group was also significantly higher than that in cTnI negative group (35.6%). There was significant difference between the two groups (P <0.01). CONCLUSIONS: Coronary lesions in cTnI-positive UA patients are complex and poor prognosis. The higher the level of cTnI, the more severe coronary stenosis, the higher the rate of short-term cardiac events.