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目的 :研究食道癌患者的红细胞免疫及细胞免疫功能。方法 :用形态学方法测定食道癌患者RBC -C3bR、RBC -IC、NTER花环率及T淋巴细胞转化率。结果 :食道癌患者RBC -C3bR花环率、NTER花环率及T淋巴细胞转化率均显著低于正常对照组 (P均 <0 0 1)。而RBC -IC花环率显著高于正常对照组 (P <0 0 1)。经手术治疗后食道癌患者RBC -C3bR花环率、NTER花环率及T淋巴细胞转化率较术前明显上升 ,但仍低于正常对照组 ;RBC -IC花环率较术前明显降低 (P<0 0 1) ,但仍高于正常对照组 (P <0 0 1)。结论 :食道癌患者红细胞免疫和细胞免疫功能均处于抑制状态 ,该检测对其发病机理探讨、疗效观察和预后判断均有一定临床意义。
Objective: To study erythrocyte immunity and cellular immunity in patients with esophageal cancer. Methods: Morphological methods were used to determine the RBC-C3bR, RBC-IC, NTER rosette rate and T lymphocyte transformation rate in patients with esophageal cancer. Results: The RBC-C3bR rosette rate, NTER rosette rate and T lymphocyte transformation rate in patients with esophageal cancer were significantly lower than those in the normal control group (all P <0.01). The RBC-IC rosette rate was significantly higher than that of the normal control group (P <0.01). The RBC-C3bR rosette rate, NTER rosette rate and T lymphocyte transformation rate of patients with esophageal cancer after operation were significantly higher than those before operation, but still lower than that of the normal control group. The RBC-IC rosette rate was significantly lower than that before operation (P <0 0 1), but still higher than the normal control group (P <0.01). Conclusion: Erythrocyte immunity and cellular immune function are both inhibited in patients with esophageal cancer. The detection of this disease may have some clinical significance for its pathogenesis, curative effect and prognosis.