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目的:探讨有创机械通气的不同实施时机对慢性阻塞性肺疾病急性发作合并重度呼吸衰竭疗效的影响.方法:选取2011-08/2014-08乌鲁木齐市友谊医院收治的62例慢性阻塞性肺疾病急性发作合并重度呼吸衰竭患者,随机分为研究组(n=31)和对照组(n=31),对照组患者行延迟机械通气,研究组行早期机械通气.使用SF-36量表评价患者生活质量,比较两组的通气指标及生活质量水平的差异.结果:研究组有创机械通气时间、机械通气总时间均短于对照组,差异具有统计学意义(P<0.05);研究组住院时间(7.14±0.56)d,少于对照组的(10.54±1.46)d,差异具有统计学意义(P<0.05);研究组治疗后SF-36各维度评分均优于对照组,差异具有统计学意义(P<0.05).结论:对COPD急性发作合并重度呼吸衰竭患者早期应用有创机械通气,能有效降低撤机困难发生率,缩短病程,显著改善患者的临床症状及生活质量.
To investigate the effect of different implementation timing of invasive mechanical ventilation on the curative effect of acute exacerbation of chronic obstructive pulmonary disease combined with severe respiratory failure.Methods: Sixty-two chronic obstructive pulmonary disease (COPD) patients admitted to Urumqi Friendship Hospital from August 2011 to August 2014 were selected, Patients with acute exacerbation and severe respiratory failure were randomly divided into the study group (n = 31) and the control group (n = 31), the control group received delayed mechanical ventilation and the study group received early mechanical ventilation.The SF-36 scale was used to evaluate the patients (P <0.05). The study group was hospitalized and the quality of life was compared between the two groups.Results: The duration of invasive mechanical ventilation and the total duration of mechanical ventilation were shorter in the study group than in the control group (P <0.05) (7.14 ± 0.56) d, less than the control group (10.54 ± 1.46) d, the difference was statistically significant (P <0.05); SF-36 scores in the study group after treatment were better than the control group, the difference was statistically (P0.05) .Conclusion: The use of invasive mechanical ventilation in patients with acute exacerbation of COPD and severe respiratory failure can effectively reduce the incidence of weaning difficulty, shorten the course of disease and significantly improve the clinical symptoms and quality of life of patients with COPD.