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目的 弄清过量氟摄入对机体的影响及干预作用。方法 选取职业性氟接触者 ,工龄 10年以上自愿者男工 60名 ,分两组。 3 0人服抗氟灵冲剂 ,3 0人服安慰剂。结果 氟接触者尿F-、血F-、尿BF4 -较非接氟者明显增多。血清IgG、IgM、IgA前者相对较低 ,AKP则明显高于后者 ,SOD活性各组间无明显差异 ,GSH Px活性前者明显低于后者。服用抗氟灵组较安慰剂组尿氟化硼排出量增加 ,且血清IgM含量、GSH Px活性升高。结论 过量氟可致机体血清免疫球蛋白和AKP、GSH Px等活性改变。抗氟灵干预有降低氟负荷、保护健康作用
Objective To understand the effect of excessive fluoride intake on the body and intervention. Methods Occupational fluoride exposure was selected. There were 60 male volunteers who were more than 10 years old and divided into two groups. 3 0 anti-fluoride agents, 30 placebo. Results Fluorine exposure of urine F-, blood F-, urine BF4 - significantly increased compared with non-fluoride. Serum IgG, IgM, IgA former is relatively low, AKP was significantly higher than the latter, SOD activity was no significant difference between the groups, GSH Px activity was significantly lower than the former. Antifluralin group than the placebo group of urinary fluoride excretion increased, and serum IgM content, GSH Px activity increased. Conclusion Excessive fluoride can cause changes in serum immunoglobulin and AKP, GSH Px and other activities. Fluoride intervention to reduce fluoride load and protect the health role