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口腔扁平苔藓(OLP)是常见的慢性粘膜皮肤疾病,常采用全身或局部应用皮质类固醇治疗。抗角化和免疫调节药物维甲酸(retinoic acid)也能成功地治疗OLP,并用于皮质类固醇治疗失败者。作者研究了肤轻松和维甲酸局部治疗萎缩型和糜烂型OLP的效果。 材料和方法 33例萎缩型和糜烂型OLP患者,男3例,女30例,年龄33～62岁,随机接受0.1％肤轻松(FAO)和0.05％维甲酸局部(RAO)治疗,每日4次,2～4周后记录OLP严重程度(以临床积分表示)和疼痛程度(疼痛积分),结果经秩和检验。 结果和讨论 FAO组18例,RAO组15例,治疗
Oral lichen planus (OLP) is a common chronic mucocutaneous disease commonly treated with systemic or topical corticosteroids. The anti-keratinizing and immunomodulating drugs retinoic acid are also successful in the treatment of OLP and are used in patients who have failed corticosteroid therapy. The authors studied the efficacy of topical and retinoic acid topical treatment of atrophic and erosive OLP. Materials and Methods 33 patients with atrophic and erosive OLP, 3 males and 30 females, aged 33 to 62 years, were randomized to receive 0.1% RA and 0.05% RAO daily. The severity of OLP (expressed as clinical score) and the degree of pain (pain score) were recorded after 2 ~ 4 weeks. The results were confirmed by rank sum test. Results and Discussion 18 patients in the FAO group and 15 in the RAO group were treated