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本文应用多聚酶链反应(PCR)方法对17例淋巴瘤患者骨髓细胞T细胞受体(TCR)Vδ_1-Jδ_1基因重排进行了检测.11例T细胞淋巴瘤中5例发生TCRVδ_1-Jδ_1基因重排,6例B细胞淋巴瘤和10例正常骨髓细胞无TCRVδ_1-Jδ_1基因重排.研究表明:TCRVδ_1-Jδ_1基因重排显示细胞系列的特异性,是T细胞恶性肿瘤的克隆标志.
In this study, polymerase chain reaction (PCR) method was used to detect the rearrangement of T cell receptor (TCR) Vδ_1-Jδ_1 genes in bone marrow cells of 17 patients with lymphoma. TCR Vδ_1-Jδ_1 gene rearrangement occurred in 5 of 11 T-cell lymphomas. 6 cases of B-cell lymphoma and 10 cases of normal bone marrow cells did not have rearrangement of TCR V delta 1 -J delta 1 gene. Studies have shown that: TCR V delta 1 -J delta 1 gene rearrangement shows the specificity of the cell line and is a cloned marker of T cell malignancy.