目的　探讨 αｓｙｎｕｃｌｅｉｎ 基因已知突变与散发性帕金森病人的关系。方法　分离 Ｐ Ｄ组和对照组的外围血基因组 Ｄ Ｎ Ａ，采用 αｓｙｎｕｃｌｅｉｎ 基因特异引物对其第四外显子进行 Ｐ Ｃ Ｒ 扩增，扩增产物用 Ｔｓｐ４５Ⅰ酶切鉴定。结果　两组 Ｐ Ｃ Ｒ 均可扩增出 ２１６ ｂｐ 的片段， Ｐ Ｃ Ｒ 产物不能被 Ｔｓｐ４５Ⅰ酶切。结论　αｓｙｎｕｃｌｅｉｎ 基因已知点突变与散发性帕金森病可能无明确关系。 Objective To investigate the relationship between the known mutation of αsynuclein gene and sporadic Parkinson’s disease. Methods Peripheral blood DNA N D of group P D and control were isolated and P C R of exon 4 was amplified by αsynuclein gene specific primers. The amplified product was identified by Tsp45 Ⅰ digestion. Results A 216 bp fragment was amplified from both P C R and P C R products could not be digested with Tsp45 Ⅰ. Conclusion α-synuclein gene known point mutation and sporadic Parkinson’s disease may not have a clear relationship.