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15只犬用乌头碱注入心室壁诱发室性心动过速(室速)后,5只不作处理为对照组,10只实验犬于对角支灌注无水乙醇(1ml.30s注完),心电监测60min后,其中4只犬再次注射无水乙醇(2ml,2s内注完).结果:治疗组与对照组室速持续时间差异有显著性(47.5±22.1s、1032.1±298.5s,P<0.001).冠状动脉(冠脉)造影及病理检查发现:小量缓慢注射乙醇可造成对角支远端闭塞及心肌非透壁坏死,大量快速注射乙醇则造成左前降支和回旋支闭塞及大面积透壁心肌坏死.实验结果提示,经冠脉注入无水乙醇可有效地终止室速,但应注意乙醇的注射量及注射速度.
Fifteen dogs were injected with aconitine into the ventricular wall to induce ventricular tachycardia (VT). Five dogs were not treated as control group. Ten dogs in the diagonal branch were injected with ethanol (1ml.30s) Sixty minutes after ECG monitoring, four of the dogs were again injected with absolute ethanol (2 ml, note within 2 seconds). Results: There were significant differences in the duration of VT between the treatment group and the control group (47.5 ± 22.1 s, 1032.1 ± 298.5 s, P <0.001). Coronary artery (coronary) angiography and pathological examination found that: a small amount of slow ethanol injection can cause diagonal branch distal occlusion and myocardial non-transmural necrosis, a large number of rapid ethanol injection is caused by left anterior descending and circumflex artery occlusion and large transmural Myocardial necrosis. Experimental results suggest that intraventricular injection of absolute ethanol can effectively terminate the ventricular rate, but should pay attention to the amount of ethanol injection and injection speed.