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闭经泌乳综合征,是由于脑垂体肿瘤或药物影响所致血清泌乳素水平升高,临床上以闭经、溢乳、不孕、更年期症状等表现为主的综合征.长期服用利血平、氯丙嗪、避孕药等可引起.我们遇到2例服用多潘立酮所致者,现报告如下.例1.患者34岁,银行职员,已婚,孕4产1,平素月经规律.因患“慢性胃炎”,常感上腹部不适、腹胀、食欲不振,服用多潘立酮(10mg,tid)后,自觉症状改善,继而经常服用.10个月后感体重逐渐增加,乏力,嗜睡,双乳发胀,挤之有乳汁溢出,闭经,而来院就诊.盆腔双合诊查子宫软,偏小,活动,双侧附体正常,排除妊娠;基础体温呈单向曲线无排卵;X线头颅侧位片未见异常,血清泌乳激素(PRL)测定为3.27nmol/L(正常0.24～0.96nmol/L).停用多潘立酮2个月后泌乳停止;3个半月后,复查血清PRL为0.76nmol/L,月经恢复正常.
Amenorrhea lactation syndrome, is due to pituitary tumor or drug-induced serum prolactin levels, clinically amenorrhea, galactorrhea, infertility, menopausal symptoms and other performance-based syndrome. Long-term use of reserpine, Azin, contraceptives, etc. We encountered two cases caused by taking domperidone, are as follows.Example 1. Patient 34 years old, bank staff, married, pregnant 4 producing 1, normal menstruation Regularly due to “chronic gastritis ”, Often feel the abdominal discomfort, abdominal distension, loss of appetite, taking domperidone (10mg, tid), the symptoms improved, and then often take.10 months later the body weight gradually increased, fatigue, lethargy, swollen breasts, crowded A case of spilled milk, amenorrhea, and to the hospital for treatment of pelvic double examination of the uterus soft, small, activities, bilateral appendages normal, excluding pregnancy; basal body temperature was unilateral ovulation; , Serum prolactin (PRL) was 3.27nmol / L (normal 0.24 ~ 0.96nmol / L) .Panostyrine was stopped after 2 months of lactation stopped; 3 and a half months later, the serum PRL was 0.76nmol / L, menstruation returned to normal .