颗粒细胞瘤(又称颗粒细胞性肌母细胞瘤)为一良性病变,常发生于皮肤、皮下组织和舌,少数见于消化道.作者报道一例食管颗粒细胞瘤,呈多中心发生且累及多脏器.病例:患者女,37岁,黑人,近10年中已从乳房、胸腹壁、背部、腿部及大阴唇切除10个颗粒细胞瘤.本次就诊前1月起出现吞咽困难,体检发现头颈、前臂、腰部、乳房及舌下均有多发性结节.食管贲门连接处在吞钡及内窥镜检查发现两个粘膜下肿块,手术病理证实为食管颗粒细胞瘤.切除后症状消失,随访10周未再出现症 Granular cell tumor (also known as granulocyte-cytomyocytoblastic tumor) is a benign lesion that often occurs in the skin, subcutaneous tissue and tongue, and is rarely found in the digestive tract. The authors reported a case of esophageal granulosa cell tumor with multiple centers and multiple involvement. Case: Patient female, 37 years old, black, had 10 granulosa cell tumors removed from the breast, thoracoabdominal wall, back, legs, and labia majora in the past 10 years. Dysphagia occurred 1 month before the current visit. Numerous nodules were found in head and neck, forearm, lumbar, breast, and sublingual tissues. Two submucosal masses were found in the esophageal cardia junction at the time of swallowing and endoscopy. The surgical pathology was confirmed as granulosa cell tumor of esophagus. The symptoms disappeared after resection. Follow-up for 10 weeks did not recur