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目的:为监测类风湿关节炎(RA)病情变化,指导RA治疗建立一个新的无损伤的实验方法。方法:用硫代巴比妥酸法测定65名正常人和67例RA患者指甲糖化蛋白(NGP),比较二者差异并研究NGP与RA患者临床表现关系。结果:NGP浓度正常对照组为4.53±1.25(μmol果糖胺/kg指甲,(?)±s,下同),RA组为12.98±9.62,两者之间有显著差异(t=7.128,P<0.001)。NGP浓度与RA临床表现密切相关:急性发作期显著升高,阳性率96.3％,急性发作期持续时间较长者NGP浓度较高。临床症状明显改善后NGP浓度下降。RA缓解期≥2个月NGP浓度可降至正常范围。结论:NGP可作为观察RA控制情况、预测病情变化、指导RA治疗的指标应用于临床。测定NGP无损伤无痛苦深受患者欢迎。
OBJECTIVE: To establish a new noninvasive experimental method for the monitoring of rheumatoid arthritis (RA) condition changes and guide RA treatment. Methods: Nigrosaccharide protein (NGP) was determined in 65 normal subjects and 67 RA patients by thiobarbituric acid method. The differences between the two groups were compared and the clinical manifestations of NGP and RA were studied. Results: The NGP concentration in control group was 4.53 ± 1.25 (μmol fructosamine / kg nails, ± s, the same below), and the RA group was 12.98 ± 9.62, with significant difference (t = 7.128, P < 0.001). The concentration of NGP was closely related to the clinical manifestations of RA: the acute exacerbation was significantly increased, the positive rate was 96.3%, and the duration of acute exacerbation was higher. After the clinical symptoms were significantly improved, the concentration of NGP decreased. The NGP concentration in the remission period> 2 months may be reduced to the normal range. Conclusion: NGP can be used as observation RA control situation, predict disease changes, guide RA treatment of indicators used in clinical. Determination of NGP without injury by patients welcome.