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B淋巴细胞刺激因子(BAFF)属于肿瘤坏死因子家族的成员,通过与3个受体(TACI、BCMA、BAFF-R)结合,发挥生物学功能,参与B、T淋巴细胞增殖和功能的调节;BAFF过度表达与受体结合后,可促使B淋巴细胞不断增殖并分泌自身抗体,从而导致一系列自身免疫性疾病的发生;BAFF过度表达,也会使淋巴细胞增殖失控,导致B细胞恶性肿瘤的发生。多发性骨髓瘤是骨髓内浆细胞异常增生的1种B细胞恶性肿瘤,恶性B细胞自分泌产生BAFF,在MM发病过程中起重要作用。
B lymphocyte stimulating factor (BAFF) is a member of the tumor necrosis factor family and functions in biological functions by binding to three receptors (TACI, BCMA, BAFF-R), and is involved in the regulation of proliferation and function of B and T lymphocytes; BAFF overexpression and receptor binding, can promote B lymphocytes continue to proliferate and secrete autoantibodies, leading to a series of autoimmune diseases; BAFF overexpression, but also make lymphocyte proliferation uncontrollable, leading to B cell malignant tumors occur. Multiple myeloma is a kind of B cell malignant tumor with abnormal proliferation of plasma cells in bone marrow. The malignant B cells autocrine produce BAFF and play an important role in the pathogenesis of MM.