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目的:中西医结合方法治疗黄体功能不足所致不孕症临床疗效观察。方法:收治门诊因黄体功能不足所致不孕症患者76例,随机分为对照组(30例)和观察组(46例),对照组患者口服地屈孕酮进行治疗,观察组在此基础上辨证服用中药。比较两组患者治疗后排卵期基础体温(BBT)上升天数;B超监测两组患者卵泡发育情况;采用酶联免疫法(ELISA)检测患者血清孕酮(P)水平;调查患者2年内受孕生育情况,判断两组患者治疗效果。结果:观察组治疗后BBT上升天数大于对照组(P<0.05);观察组卵泡16～20 mm者有37例(80.4/%),明显高于对照组17例(56.7%)(P<0.01);治疗后观察组患者孕酮高于对照组(P<0.05)。观察组痊愈35例(76.1%),痊愈患者全部妊娠12周成功并足月生产,有效10例(21.7%),无效1例(2.2%),总有效率97.8%;对照组痊愈16例(53.3%),痊愈者中14例足月生产,1例早产,1例流产。对照组有效7例(23.3%),无效7例(23.3%),总有效率76.7%,两组比较差异有明显统计学差异(P<0.05或P<0.01)。结论:地屈孕酮联合中药的辨证治疗黄体功能不足所致不孕症效果好。
Objective: To observe the clinical effect of integrative traditional Chinese and western medicine on infertility caused by corpus luteum insufficiency. Methods: A total of 76 patients with infertility due to inadequate luteal function in outpatients were randomly divided into control group (n = 30) and observation group (n = 46). The control group received oral dydrogesterone treatment. Dialectical use of traditional Chinese medicine. The days of basal body temperature (BBT) rise in ovulation period were compared between the two groups. Follicle development in both groups was monitored by B-mode ultrasonography. Serum progesterone (P) level was measured by enzyme-linked immunosorbent assay (ELISA) Situation, to determine the treatment effect of two groups of patients. Results: The days of BBT rise in observation group were significantly higher than those in control group (P <0.05). The observation group had 37 (80.4%) cases of follicular at 16-20 mm, which was significantly higher than that in control group (56.7%) (P <0.01) ); After treatment, the progesterone in the observation group was higher than that in the control group (P <0.05). In the observation group, 35 cases (76.1%) were cured, and all the patients were cured and were born at full 12 weeks of gestation. The effective rate was 97.9% in 10 cases (21.7%), ineffective in 1 case (2.2% 53.3%), 14 cases of full-term recovery were cured, 1 case of premature delivery, 1 case of abortion. The control group was effective in 7 cases (23.3%), ineffective in 7 cases (23.3%), the total effective rate was 76.7%. There was significant difference between the two groups (P <0.05 or P <0.01). Conclusion: The effect of dydrogesterone combined with traditional Chinese medicine in treating infertility caused by insufficient function of corpus luteum is good.