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目的探讨糖尿病视网膜病变(DR)患者血小板平均体积(MPV)与视网膜厚度(RT)及尿清蛋白排泄率(UAER)的关系及意义。方法对2004年4月至2006年7月新乡医学院第一附属医院诊治的55例DR患者(DR组)MPV、RT及UAER进行测定,并与30名健康对照组比较。结果DR组MPV、RT及UAER均显著高于健康对照组(P<0.01);DR患者尿清蛋白大量组MPV和RT显著高于尿清蛋白正常组(P<0.01)和尿清蛋白微量组(P<0.01或P<0.05),尿清蛋白微量组显著高于尿清蛋白正常组(P<0.01或P<0.05);RT与MPV及UAER均呈正相关(r=0.547,P<0.05;r=0.823,P<0.01)。结论MPV、RT及UAER的检测,对DR的发生发展及早期诊断和治疗具有重要意义,是反映DR微血管病变程度及病变范围的指标。
Objective To investigate the relationship between mean platelet volume (MPV) and retinal thickness (RT) and urinary albumin excretion (UAER) in patients with diabetic retinopathy (DR). Methods The MPV, RT and UAER of 55 DR patients (DR group) diagnosed and treated in the First Affiliated Hospital of Xinxiang Medical College from April 2004 to July 2006 were measured and compared with 30 healthy controls. Results The MPV, RT and UAER in DR group were significantly higher than those in healthy control group (P <0.01). The MPV and RT in large amount of urine albumin in DR patients were significantly higher than those in normal urine samples (P <0.01) and urine albumin microarray (P <0.01 or P <0.05). The levels of urinary albumin in trace group were significantly higher than those in normal urine albumin group (P <0.01 or P <0.05). There was a positive correlation between RT and MPV and UAER (r = 0.547, r = 0.823, P <0.01). Conclusion The detection of MPV, RT and UAER is of great significance to the occurrence, development and early diagnosis and treatment of DR. It is an index reflecting the extent of DR microangiopathy and the range of disease.