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采用正交试验法 ,确定了尼美舒利缓释片的最佳处方和制备工艺 ,体外释放度试验的 8h累积释放量大于75 %,其释放行为符合 Higuchi方程。
Orthogonal test was used to determine the best formulation and preparation process of nimesulide sustained-release tablets. The release in vitro was more than 75% in 8h and the release behavior was consistent with Higuchi equation.