噻托溴胺(Tiotropium,TP)治疗慢性阻塞性肺疾患(COPD)比沙美特罗(salmeterol,ST)更有效。但这一药效持久的吸入类抗胆碱能药物尚未得到批准使用。 意大利热那亚大学的V. Brusasco及其同事指出,每天用TP治疗有利于延缓COPD病情恶化和有效使用卫生资源。除了与各种原因有关的住院天数外,每天服用2次ST与服用安慰剂相比,并无显著差异。 Tiotropium (TP) is more effective than salmeterol (ST) in the treatment of chronic obstructive pulmonary disease (COPD). However, this long-lasting inhaled anticholinergic drug has not yet been approved for use. V. Brusasco, of the University of Genoa, Italy, and colleagues point out that daily treatment with TP helps to delay the deterioration of COPD and to make effective use of health resources. In addition to the number of days hospitalized for various reasons, taking ST twice daily did not differ significantly from taking placebo.