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肾小球硬化是多种慢性肾脏疾病进展至终末期肾衰的主要病理基础 ,在这一过程中 ,基质金属蛋白酶及其组织抑制因子失衡所致的细胞外基质的积聚发挥着重要作用[1] 。研究表明 ,冬虫夏草 (Cordycepssinensis)能拮抗氨基糖甙类肾毒性 ;减少尿蛋白 ;改善CsA肾中毒大鼠的肾小管损害 ;
Glomerulosclerosis is the main pathological basis for the progression from multiple chronic kidney diseases to end-stage renal failure. During this process, the accumulation of extracellular matrix due to the imbalance between matrix metalloproteinases and their tissue inhibitors plays an important role [1 ]. Studies have shown that Cordyceps sinensis can antagonize aminoglycoside nephrotoxicity, reduce urinary protein, and improve renal tubular damage in rats with CsA nephrotoxicity.