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目的:评价米索前列醇(简称米索)及卡孕栓在早期妊娠人工流产术前阴道用药的宫颈扩张作用。方法:400μg米索或1mg卡孕栓被术前2～5小时分别放置妊娠5～10周妇女阴道后穹窿内,记录每例患者宫颈的扩张程度及腹痛、出血等副作用。结果:当药物作用3.5小时以内时,两组宫颈扩张作用的差异尚不明显。3.5小时后卡孕栓扩张宫颈的作用则明显优于米索。阴道内术前用药超过3.5小时无论米索组或卡孕栓组与其自身比较,宫颈扩张的作用均较用药3.5小时以内的作用明显提高。卡孕栓组较米索组腹痛等胃肠道副反应的发生率高。结论:米索及卡孕栓在早期妊娠人工流产术前阴道用药有较强的宫颈扩张作用。米索副作用相对较少,适于人工流产前的宫颈扩张的常规用药。妊娠天数较长,胚胎较大,人流手术相对困难者使用卡孕栓较为合理。上述药物术前阴道使用推荐时间为至少3.5小时。
OBJECTIVE: To evaluate the cervical dilation effect of misoprostol (referred to as misoprostol) and carbamazepine vaginally before artificial abortion in early pregnancy. Methods: 400μg misoprostol or 1mg carbamazepine were placed in vaginal fornix for 5 ~ 10 weeks after operation for 2 ~ 5 hours respectively. The cervical dilatation, abdominal pain and hemorrhage were recorded in each patient. Results: When the drug effect within 3.5 hours, the difference between the two groups of cervical dilatation is not yet obvious. 3.5 hours after the expansion of cervical caesarean suppository is significantly better than misoprostol. Intravaginal preoperative medication for more than 3.5 hours No matter the misoprostol group or the captopril group compared with itself, the effect of cervical dilation was significantly higher than the role of medication within 3.5 hours. Carprost suppository group than misoprostol abdominal pain and other gastrointestinal side effects of high incidence. Conclusion: Misoprostol and carboplatin suppository have good cervical dilatation before vaginal administration in early pregnancy induced abortion. Miso side effects are relatively small, suitable for routine use of cervical dilatation before artificial abortion. Pregnancy is longer, larger embryos, abortion is relatively difficult to use carbamazepine more reasonable. The recommended time for preoperative vaginal use of these medications is at least 3.5 hours.