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目的:研究急性心肌梗死(AMI)患者外周血T淋巴细胞及其亚群和血清C反应蛋白(CRP)的变化,探讨两者之间的相关性。方法:采用流式细胞仪技术测定33例AMI患者外周血T淋巴细胞及其亚群,并与对照组的30例比较;采用免疫散射比浊法测定33例AMI患者血清CRP的系列变化值,取其峰值。结果:AMI患者外周血CD3+和CD4+显著低于对照组(P<0.01),CD8+无明显改变(P>0.05),CD4+/CD8+比值明显低于对照组(P<0.01);CRP峰值与CD4+/CD8+比值呈显著的负相关(r=-0.731,P<0.01)。结论:AMI患者细胞免疫功能受到抑制,T细胞亚群的变化与炎症因子CRP有相关性,炎症因子及免疫机制可能都是影响AMI患者病情进展的重要因素。
Objective: To study the changes of peripheral blood T lymphocyte subsets and serum C-reactive protein (CRP) in patients with acute myocardial infarction (AMI) and to explore the correlation between the two. Methods: Flow cytometry was used to determine the T lymphocyte subsets in peripheral blood of 33 cases of AMI patients and compared with the control group (30 cases). Serum CRP levels in 33 patients with AMI were measured by immune nephelometry. Take its peak. Results: The levels of CD3 + and CD4 + in peripheral blood of patients with AMI were significantly lower than those of the control group (P <0.01), but there was no significant change of CD8 + (P> 0.05) and the ratio of CD4 + / CD8 + CD8 + ratio showed a significant negative correlation (r = -0.731, P <0.01). CONCLUSIONS: The cellular immune function is inhibited in AMI patients. The changes of T cell subsets are correlated with the inflammatory factor CRP. Inflammatory factors and immune mechanisms may all play an important role in the progression of AMI.