先证者,男,32岁。左侧鼻塞伴涕中带血20天。家族中无近亲婚配史。体检:系统检查未见异常。耳鼻喉科检查见左鼻腔紫色肿物充满,表面部分坏死,边界不清,质软,易出血。皮肤科情况:颈及肩背部不规则散在一些血管性小结节,鲜红色,呈圆形高出皮面,表皮光滑,质软,可压缩,边缘清楚,玻片 The proband, male, 32 years old. The left stuffy nose with bloody sputum for 20 days. There is no history of marriage in the family. Physical examination: no abnormal system examination. The otolaryngologic examination showed that the purple tumor in the left nasal cavity was full, the surface was partially necrotic, the boundary was unclear, and it was soft and prone to bleeding. Department of Dermatology: Irregularly scattered small vascular nodules in the neck, shoulders and back, bright red, round and above the skin, smooth skin, soft, compressible, clear edges, slides