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目的观察福莫特罗干粉治疗儿童哮喘急性发作及长期控制的疗效。方法通过随机分组,将98例患儿分为二组,观察组:48例,给予福莫特罗干粉4.5μg,加布地奈德干粉100μg,早晚2次吸入;对照组给予布地奈德干粉200μg,早晚2次吸入。观察用药前、后患儿症状、体征(咳嗽、喘息、喘鸣音)改善情况及FEV1%、PEF%评估。结果治疗后观察组、对照组患儿的临床症状、体征及FEV1%、PEF%均有明显改善(P<0.001)。观察组临床症状、体征改善,优于对照组(P<0.01)。结论应用小剂量福莫特罗加小剂量吸入性激素与对照组双倍剂量吸入激素疗效相似,副作用少,不但可以在哮喘急性发作期应用,而且可以在儿童哮喘长期防治中应用,依从性高,并可减轻家长对大剂量激素的恐惧心理,值得临床推广应用。
Objective To observe the efficacy of formoterol powder in the treatment of acute asthma in children and long-term control. Methods A total of 98 children were randomly divided into two groups: observation group (48 cases), propofol powder (4.5μg), budesonide (100μg) and inhalation (twice a day). The control group received budesonide 200μg , 2 times sooner or later inhaled. Observed before and after treatment in children with symptoms and signs (cough, wheeze, wheezing) improvement and FEV1%, PEF% assessment. Results After treatment, the clinical symptoms, signs and the FEV1% and PEF% of the observation group and the control group were significantly improved (P <0.001). Clinical symptoms and signs in observation group were better than those in control group (P <0.01). Conclusion The application of small dose of formoterol and small dose inhaled hormones with double dose of inhaled hormones has similar curative effect and less side effects. It not only can be used in the acute exacerbation of asthma, but also can be used in long-term prevention and treatment of asthma in children, with high compliance, And reduce the fear of high doses of hormones for parents, it is worth to clinical application.