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肝糖元的分解糖元的磷酸解作用早在1936年,Parnas氏就发现组织浸出液分解糖元时必须有无机磷酸监的存在。据此,他假定糖元的分解并不是单纯的水解作用而是以磷酸代替水来分解的,他称这种分解作用为磷酸解作用,所需的酶为磷酸化酶。倘若他的假定是正确的,则糖元磷酸解的产物必然是磷酸葡萄糖。Cori与Cori(1936)证明这是正确的,并指出反应产物是葡萄糖-1-磷酸。二年后Kiessling提纯了葡萄糖-1-磷酸,因而证实Cori与Cori的实验。其后Kiessling(1939)发现肝、肌肉及酵母的磷酸化酶,可以把葡
Decomposition of glycogen Glycogen phospholysis As early as 1936, Parnas’s found that tissue leachate decomposition glycogen must have inorganic phosphate monitoring presence. Accordingly, he assumes that the glycogen decomposition is not a mere hydrolysis but a decomposition by phosphoric acid instead of water, which he calls phospholysis, and the enzyme required is phosphorylase. If his hypothesis is correct, the product of glycogen phosphorylation must be phosphoglucose. This is corroborated by Cori and Cori (1936), pointing out that the reaction product is glucose-1-phosphate. Two years later Kiessling purifies glucose-1-phosphate, confirming Cori’s experiment with Cori. Later Kiessling (1939) found that liver, muscle and yeast phosphorylase, can put the Portuguese