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选择临床确诊糖尿病性脊髓病24例,在积极控制血糖、血压基础上,均联合给予前列地尔与α-硫辛酸治疗,疗程4周,观察患者治疗前后神经系统症状及体征变化,并测定治疗前后患者脊髓传导速度(SCCV)、运动神经传导速度(MNCV)及感觉神经传导速度(SNCV)。结果经前列地尔联合α-硫辛酸治疗后,患者神经系统症状及体征均明显好转,SCCV、MNCV、SNCV与治疗前相比均有显著性差异(P<0.05)。结论前列地尔联合α-硫辛酸是糖尿病性脊髓病安全、有效的治疗方法。
Select the clinical diagnosis of diabetic myelopathy in 24 cases, in the active control of blood glucose, blood pressure, are given in combination with alprostadil and α-lipoic acid treatment, the course of 4 weeks, observed before and after treatment of patients with neurological symptoms and signs and measures of treatment Spinal cord conduction velocity (SCCV), motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) before and after treatment. Results After treatment with alprostadil combined with α-lipoic acid, the symptoms and signs of neurological symptoms were significantly improved in patients with SCCV, MNCV and SNCV compared with that before treatment (P <0.05). Conclusion Alprostadil combined with α-lipoic acid is a safe and effective treatment for diabetic myelopathy.