通过体外胎肝细胞四氯化碳(CCl_4)中毒模型,研究联苯双酯对人胎肝细胞膜表面超微结构的保护作用。结果表明,联苯双酯对肝细胞膜表面结构具有明显的稳定作用,能增强肝细胞的抗损伤能力,对肝细胞谷丙和谷草转氨酶的释放均有明显的降低作用,从而提出联苯双酯的降转氨酶机理很可能是通过对肝细胞膜系统的稳定作用而实现的。 The protective effect of bifendate on the ultrastructure of human fetal liver cell membrane was studied by the model of carbon tetrachloride (CCl_4) poisoning in fetal liver cells. The results showed that bifendate had a significant stabilizing effect on the surface structure of hepatic cell membranes, which could enhance the ability of hepatocytes to resist damage and significantly reduce the release of hepatic gluten-propione and aspartate aminotransferase, thus suggesting biphenyl diesters. The mechanism of aminotransferase reduction is likely to be achieved through stabilization of the hepatocyte membrane system.