To the Editor:Non-arteritic anterior ischemic optic neuropathy (NAION),characterized by a sudden onset of unilateral painless visual loss and a swollen optic disc,is the most common form of acute optic neuropathy in patients over 50 years of age.[1] The pathogenesis of NAION remains unclear,but most histopathological studies support the concept of vasculopathic occlusion in the region of the short posterior ciliary arteries.[2] Functional magnetic resonance imaging (fMRI) is one of the most widely used non-invasive techniques for measuring brain function over time in vivo.To the best of our knowledge,only one study has investigated the effects of stimulating the affected eye in the extra-visual areas in NAION in humans.[3] However,this previous study only examined task-state fMRI,and lacked a measure of resting-state fMRI (rs-fMRI).Thus,it remains unclear whether regional spontaneous brain changes are limited to the visual system.