大麻类物质通过与免疫细胞表面抑制性G蛋白偶联受体CB1和CB2结合 ,调节免疫细胞的功能和细胞因子的产生。大麻受体可根据组织分布不同分为中枢型和外周型两类 ,前者主要分布在脑组织中而后者主要分布在免疫细胞表面。绝大多数大麻类物质具有结合两种类型受体的能力 ,而且内源性大麻可以快速通过血脑屏障 ,提示其可能是神经 免疫轴中的活跃递质。 Cannabinoids regulate immune cell function and cytokine production by binding to the immune cell surface inhibitory G protein-coupled receptors CB1 and CB2. Cannabinoid receptors can be divided into two types: central and peripheral, depending on tissue distribution. The former are mainly distributed in the brain and the latter are mainly distributed on the surface of immune cells. The vast majority of cannabis compounds have the ability to bind both types of receptors, and endogenous cannabis can rapidly pass through the blood-brain barrier, suggesting that it may be an active transmitter in the nervous immune axis.