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目的 探讨米诺地尔在维持性血液透析患者中的降压作用。方法 11例血液透析伴顽固性高血压患者 ,在服用常规降压药基础上使用米诺地尔 ,分析其的降压效果及其副作用。结果 米诺地尔治疗 1月后显效率 95 % (10 / 11) ,有效率 10 0 % (11/ 11) ;治疗 3月后显效率 10 0 %。近期对血肌酐无明显影响。副作用观察 :当患者服用的剂量为 5 .0mg/d时 ,其在一月后都出现不同程度的多毛现象 ;当米诺地尔剂量为 2 .5mg/d时 ,患者多毛有所减少。未见明显心率增快、心包积液及水钠潴留。结论小剂量米诺地尔在配合其它降压药的基础上 ,对伴顽固性高血压的血液透析患者降压效果肯定 ,副作用可以耐受。
Objective To investigate the antihypertensive effect of minoxidil in maintenance hemodialysis patients. Methods Eleven patients with hemodialysis and refractory hypertension were treated with minoxidil on the basis of conventional antihypertensive drugs, and their antihypertensive effect and side effects were analyzed. Results Minoxidil showed a significant efficiency of 95% (10/11) after 1 month of treatment, with an effective rate of 10% (11/11). After 3 months of treatment, the effective rate was 100%. Recently, no significant effect on serum creatinine. Side effects observed: when the patient taking a dose of 5.0mg / d, after a month they all showed varying degrees of hirsutism; when the minoxidil dose of 2.5mg / d, the hoe decreased. No significant increase in heart rate, pericardial effusion and Shuinazhuliu. Conclusions The low dose of minoxidil, combined with other antihypertensive drugs, is effective in reducing blood pressure in hemodialysis patients with refractory hypertension. The side effects can be tolerated.