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实验观察了正常对照组,单纯高胆固醇血症组和高胆固醇血症加静脉注射粪链球菌组胸主动脉内皮细胞表面粘附的单核细胞数、内皮细胞、血脂和动脉壁胆固醇含量的变化。与正常对照组比较,高胆固醇血症组和加静脉注射粪链球菌组粘附单核细胞数增多,内皮细胞间隙增宽,但后两组间差异无显著性;血清胆固醇和甘油三酯含量及动脉壁胆固醇含量也显著增加,且加静脉注射粪链球菌组明显高于单纯高胆固醇血症组。相关回归分析发现动脉壁胆固醇含量与血症胆固醇含量有显著相关性,而与粘附单核细胞数无明显相关性。因此作者认为单核细胞粘附侵入内膜不是血浆胆固醇进入血管壁的主要途径,而内皮细胞损伤等因素可能起了重要作用。
The number of mononuclear cells adhered on the surface of thoracic aorta endothelial cells, endothelial cells, lipids, and arterial wall cholesterol content in normal control group, hypercholesterolemia group, hypercholesterolemia group, and streptococcus faecalis group were observed. . Compared with the normal control group, the number of adherent mononuclear cells in the hypercholesterolemia group and the intravenous streptococcus group increased, and the width of the endothelial cells widened, but there was no significant difference between the two groups; serum cholesterol and triglyceride content And arterial wall cholesterol content also increased significantly, and the addition of intravenous streptococcus group was significantly higher than the hypercholesterolemia group alone. Regression analysis found that there was a significant correlation between the cholesterol content in the arterial wall and the cholesterol content in the disease, but there was no significant correlation with the number of adherent mononuclear cells. Therefore, the authors believe that monocyte adhesion to the intima is not the main route of plasma cholesterol into the blood vessel wall, and endothelial cell damage and other factors may play an important role.